5-Chloro-2-hydroxy-3-nitro-(1,1-biphenyl)-3-carboxylic acid
5'-Chloro-2'-hydoxy-3'-nitro-(1,1'-biphenyl)-3-Carboxylic acid
CAS: 376592-58-4
Molecular Formula: C13H8ClNO5
5-Chloro-2-hydroxy-3-nitro-(1,1-biphenyl)-3-carboxylic acid - Names and Identifiers
| Name | 5'-Chloro-2'-hydoxy-3'-nitro-(1,1'-biphenyl)-3-Carboxylic acid |
| Synonyms | Eltrombopag int1 Eltrombopag Impurity 15 Eltrombopag Impurity 39 3-(5-chloro-2-hydroxy-3-nitrophenyl)benzoic acid 5'-Chloro-2'-hydroxy-3'-nitrobiphenyl-3-carboxylic acid 5-Chloro-2-hydroxy-3-nitro-(1,1-biphenyl)-3-carboxylic acid 5'-Chloro-2'-hydoxy-3'-nitro-(1,1'-biphenyl)-3-Carboxylic acid [1,1'-Biphenyl]-3-carboxylic acid, 5'-chloro-2'-hydroxy-3'-nitro |
| CAS | 376592-58-4 |
| EINECS | 1592732-453-0 |
| InChI | InChI=1S/C13H8ClNO5/c14-9-5-10(12(16)11(6-9)15(19)20)7-2-1-3-8(4-7)13(17)18/h1-6,16H,(H,17,18) |
5-Chloro-2-hydroxy-3-nitro-(1,1-biphenyl)-3-carboxylic acid - Physico-chemical Properties
| Molecular Formula | C13H8ClNO5 |
| Molar Mass | 293.66 |
| Density | 1.549±0.06 g/cm3(Predicted) |
| Boling Point | 467.4±45.0 °C(Predicted) |
| pKa | 3.89±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
5-Chloro-2-hydroxy-3-nitro-(1,1-biphenyl)-3-carboxylic acid - Introduction
5 '-Chloro-2'-hydoxy-3 '-nitro-(1,1'-biphenyl)-3-Carboxylic acid is an organic compound with the chemical formula C13H8ClNO4. It is a yellow solid, soluble in alcohol and ketone, almost insoluble in water.
The compound is often used as an important intermediate in organic synthesis and medicinal chemistry. As a benzodiazepine derivative, it has a wide range of applications. For example, it can be used in the synthesis of drugs and pesticides, and also in the preparation of electrochemical materials.
There are many ways to prepare 5 '-Chloro-2'-hydoxy-3-nitro-(1,1 '-biphenyl)-3-Carboxylic acid. One of the commonly used methods is through the oxidation of benzodiazepine intermediates. Specifically, the target product can be obtained by oxidation treatment of the benzodiazepine substance, and then through substitution reaction and carboxylation reaction. This process needs to be carried out under appropriate reaction conditions.
Regarding safety information, 5 '-Chloro-2'-hydoxy-3 '-nitro-(1,1'-biphenyl)-3-Carboxylic acid is a toxic substance that is irritating and corrosive. Necessary safety precautions, such as wearing protective gloves, glasses and protective clothing, should be taken when handling the compound. And make sure to operate in a well-ventilated place to avoid breathing gas or contact with skin. Any contact with this compound should be immediately rinsed with plenty of water and treated with medical attention.
The compound is often used as an important intermediate in organic synthesis and medicinal chemistry. As a benzodiazepine derivative, it has a wide range of applications. For example, it can be used in the synthesis of drugs and pesticides, and also in the preparation of electrochemical materials.
There are many ways to prepare 5 '-Chloro-2'-hydoxy-3-nitro-(1,1 '-biphenyl)-3-Carboxylic acid. One of the commonly used methods is through the oxidation of benzodiazepine intermediates. Specifically, the target product can be obtained by oxidation treatment of the benzodiazepine substance, and then through substitution reaction and carboxylation reaction. This process needs to be carried out under appropriate reaction conditions.
Regarding safety information, 5 '-Chloro-2'-hydoxy-3 '-nitro-(1,1'-biphenyl)-3-Carboxylic acid is a toxic substance that is irritating and corrosive. Necessary safety precautions, such as wearing protective gloves, glasses and protective clothing, should be taken when handling the compound. And make sure to operate in a well-ventilated place to avoid breathing gas or contact with skin. Any contact with this compound should be immediately rinsed with plenty of water and treated with medical attention.
Last Update：2024-04-09 20:02:46
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